What value do we expect for the pKa of a protein's C-terminal
carboxylate? pKa values for free amino acids are quite low (2-3),
but it seems to me that this may have something to do with the
proximity of a free amine group; I'd expect a higher value (4-ish?)
for the peptide's C-terminus.
A quick & lazy search using the term "pka" was stymied by a gazillion
references to protein kinase A...
Thanks,
Pat
------------------------------------------------------------------------
---------------
Patrick J. Loll, Ph. D.
Professor of Biochemistry & Molecular Biology
Director, Biochemistry Graduate Program
Drexel University College of Medicine
Room 10-102 New College Building
245 N. 15th St., Mailstop 497
Philadelphia, PA 19102-1192 USA
(215) 762-7706
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