You are correct. See */Protein Sci/* Thurlkill et al. 15 (5): 1214,
http://www.proteinscience.org/cgi/reprint/15/5/1214, which is a recent
effort to codify "typical" pKa values for protein ionizable groups.
Cheers,
--
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Roger S. Rowlett
Professor
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Department of Chemistry
Colgate University
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Patrick Loll wrote:
What value do we expect for the pKa of a protein's C-terminal
carboxylate? pKa values for free amino acids are quite low (2-3), but
it seems to me that this may have something to do with the proximity
of a free amine group; I'd expect a higher value (4-ish?) for the
peptide's C-terminus.
A quick & lazy search using the term "pka" was stymied by a gazillion
references to protein kinase A...
Thanks,
Pat
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Patrick J. Loll, Ph. D.
Professor of Biochemistry & Molecular Biology
Director, Biochemistry Graduate Program
Drexel University College of Medicine
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