> Bias is defined as 'difference from expectation', so the isotropic model > is almost certainly biased, as reflected in the higher-than-expected > Rwork & Rfree.
Phil, sorry in my rush to go home I explained that badly: bias is defined as 'difference between the expected and true values'. In this case the expectation is the Rfree (or other statistic) that you would expect to get based on the isotropic model, and we're assuming that the optimally parameterised ADP model (whatever it is) is the one closest to the truth: this may of course be a rash assumption since even the optimal parameterisation may well not explain all the errors in the model. The bias in Rfree for the isotropic model is the difference between these. Cheers -- Ian Disclaimer This communication is confidential and may contain privileged information intended solely for the named addressee(s). It may not be used or disclosed except for the purpose for which it has been sent. If you are not the intended recipient you must not review, use, disclose, copy, distribute or take any action in reliance upon it. If you have received this communication in error, please notify Astex Therapeutics Ltd by emailing i.tic...@astex-therapeutics.com and destroy all copies of the message and any attached documents. Astex Therapeutics Ltd monitors, controls and protects all its messaging traffic in compliance with its corporate email policy. The Company accepts no liability or responsibility for any onward transmission or use of emails and attachments having left the Astex Therapeutics domain. Unless expressly stated, opinions in this message are those of the individual sender and not of Astex Therapeutics Ltd. The recipient should check this email and any attachments for the presence of computer viruses. Astex Therapeutics Ltd accepts no liability for damage caused by any virus transmitted by this email. E-mail is susceptible to data corruption, interception, unauthorized amendment, and tampering, Astex Therapeutics Ltd only send and receive e-mails on the basis that the Company is not liable for any such alteration or any consequences thereof. Astex Therapeutics Ltd., Registered in England at 436 Cambridge Science Park, Cambridge CB4 0QA under number 3751674
