*A post-doctoral position *is available immediately in the group of Laurent Terradot at the Institut de Biologie et Chimie des Protéines (IBCP), Lyon, (http://www.ibcp.fr). We are interested in the structure/function of protein complexes involved in /Helicobacter pylori /pathogenesis. This bacteria is a major pathogen that causes human diseases such as ulcers and gastric cancers. Several projects are available in our laboratory to study 1) virulence factors/receptor interactions (see Tosi /et al/., Febs L, 2009; Angelini /et al/., Febs Journal, 2009; Jimenez-Soto /et al/., PloS Pathogens, 2009) and 2) DNA replication regulation (see Natrajan et al., Mol. Microbiology, 2007; Natrajan et al., PNAS, 2009). Part of the work will be carried out with National and International collaborations.

The IBCP is well equipped for Molecular Biology, Biochemistry, Bioinformatics and Structural Biology and belongs to a larger campus (Lyon Biopole; Center for Infectiology), giving access to state-of-the-art core facilities. The group has regular access to synchrotron beam time and is ideally located one hour from the European Synchrotron ESRF. Lyon is a vibrant, historical French city and is a world-excellence center in Infectiology.

We are looking for enthusiastic and self-motivated individuals with a strong background in protein purification for structural studies. Experience in protein-protein interactions (Biacore, ITC, etc...) and/or study of large complexes would be a plus. Knowledge in Macromolecular Crystallography would be considered an advantage but is not mandatory as training can be provided. Working language of the laboratory is English.

Starting date: *As soon as possible*.

Salary is according to the CNRS french guidelines and will depend on experience.

Please send a cover letter, your CV and one (or more) reference letter as a single PDF file to: *laurent.terra...@ibcp.fr <mailto:laurent.terra...@ibcp.fr>
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Deadline: May the 1st, 2010.
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Laurent Terradot
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Institut de Biologie et Chimie des proteines
ATIP-CNRS Group Structural Biology of Bacterial Macromolecular Complexes
UMR 5086 CNRS Université de Lyon
7, passage du Vercors
69367 Lyon cedex 07 FRANCE

tel: +33 (0) 472 72 2652
Fax: +33 (0) 472 72 2604
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