Well BR, do not underestimate complexity of running a gel! There are even more harsh referees comments on gel appearance and quality than comments on cutting data based on R,RF and sigmaI :-) Especially when one is trying to penetrate into prestigious journals... Dr Felix Frolow Professor of Structural Biology and Biotechnology Department of Molecular Microbiology and Biotechnology Tel Aviv University 69978, Israel
Acta Crystallographica F, co-editor e-mail: mbfro...@post.tau.ac.il Tel: ++972-3640-8723 Fax: ++972-3640-9407 Cellular: 0547 459 608 On Mar 3, 2011, at 18:38 , Bernhard Rupp (Hofkristallrat a.D.) wrote: >> related to what I feel is recent revival of the significance of the R-values > > ....because it's so handy to have one single number to judge a highly complex > nonlinear multivariate barely determined regularized problem! Just as easy as > running a gel! > > Best BR > > -----Original Message----- > From: CCP4 bulletin board [mailto:CCP4BB@JISCMAIL.AC.UK] On Behalf Of Ed > Pozharski > Sent: Thursday, March 03, 2011 8:19 AM > To: CCP4BB@JISCMAIL.AC.UK > Subject: Re: [ccp4bb] I/sigmaI of >3.0 rule > > On Thu, 2011-03-03 at 08:08 -0700, Bart Hazes wrote: >> I don't know what has caused this wave of high I/Sigma threshold use >> but here are some ideas >> > > It may also be related to what I feel is recent revival of the significance > of the R-values in general. Lower resolution cutoffs in this context improve > the R-values, which is (incorrectly) perceived as model improvement. > > -- > "I'd jump in myself, if I weren't so good at whistling." > Julian, King of Lemurs
