Hi all,
I have data indexed in I23 with ~3000 unique reflections. Having set aside 10% of these my refinements still go berserk. The maps do look fine though. The same happens when reindexed in lower symmetries. Phenix autobuild finishes for example with 28/40 and I get similiar results (although it took me longer) tracing manually and refining with refmac. Does it make sense to set aside 500 reflections in my case, which would be ~17% of the data? What is the correct way to deal with data of this type? Ignoring the Rfree completely? A nice weekend to all, Aaron