At AstraZeneca, we're constantly striving to make new discoveries. Discoveries that will make a meaningful difference to health globally. We already have an exceptional product pipeline, and everyone here has a part to play in making sure that pipeline fulfills its potential. This is your opportunity to join them - and to fulfill your own.
We have an exciting opportunity for a biochemist / biophysicist / crystallographer to join the Structure & Biophysics group at AstraZeneca in Waltham, MA. This is a collaborative effort with the laboratory of Professor Jamie Cate at the University of California Berkeley to understand the structural basis of mechanism-based toxicity to antibiotic treatment. Success in generating chimeric ribosomes will result in novel means to assess antibacterial sensitivity using a suite of genetic, biochemical and biophysical approaches. This position provides an opportunity to explore the gene-to-structure process in an industrial setting. You'll be exposed to a variety of aspects within the drug discovery cascade, and will interact with scientists in a cross-disciplinary environment. You'll also be expected to deliver your novel research results within AstraZeneca, and externally via scientific conferences and peer-reviewed publications. * Build an understanding of antibiotic selectivity for the bacterial ribosome through the design and analysis of the functional activity of chimeric ribosomes * Assess the antibacterial sensitivity of recombinant bacterial strains containing chimeric ribosomes against a panel of known ribosomal inhibitors * Understand the structural basis of ribosomal inhibitor selectivity by performing crystallography on chimeric ribosomes in complex with antibiotics * Work collaboratively with scientists across various disciplines to achieve project objectives * Externally present results at scientific conferences, and publish scientific papers in high quality peer-reviewed journals A PhD in one or more of the following areas: * Protein/RNA biochemistry * Biophysics, crystallography, ribosome biology, molecular microbiology * Molecular biology, expression and purification skills to independently produce high-quality RNA-protein complexes * Experience with multiple biochemical and biophysical techniques to assess the quality, stability and function of RNA-protein complexes * Experience in performing antibacterial sensitivity assays * Experience in designing complex reagents for biophysical and crystallographic studies * Crystallographic experience is highly desirable * Strong written and oral communication skills As one of the world's leading pharmaceutical companies, our business is focused on providing innovative, effective medicines that make a real difference in important areas of healthcare. What's more, we support and encourage our people in discovering their own potential. Excellent learning and development opportunities will be available to you throughout your career here. Please follow this link to view the full advertisement and online application: http://jobs.astrazeneca.com/jobs/23176-postdoctoral-position-synthetic-b iology-to-probe-ribosomal-inhibitor-selectivity -------------------------------------------------------------------------- Confidentiality Notice: This message is private and may contain confidential and proprietary information. If you have received this message in error, please notify us and remove it from your system and note that you must not copy, distribute or take any action in reliance on it. Any unauthorized use or disclosure of the contents of this message is not permitted and may be unlawful.
