A *post-doctoral position* is available to study the molecular mechanism for self vs. non-self discrimination by the innate immune system. We use a combination of X-ray crystallography, biochemistry and cell biology to characterize structures and functions of key host molecules that recognize foreign molecules, in particular viral nucleic acids.
Applicants should have received a PhD and have a strong background in X-ray crystallography, biochemistry, RNA biology, immunology or virology. Please send a cover letter, CV, names, e-mail addresses and telephone numbers of three references to Sun Hur at sun....@childrens.harvard.edu<h...@idi.harvard.edu> For more information, visit http://labs.idi.harvard.edu/hur/ Relevant papers 1. Wu B, Peisley A, Richards C, Yao H, Zeng Z, Lin C, Chu F, Walz T & Hur S. Structural Basis for dsRNA recognition, filament formation and antiviral signaling by MDA5. Cell, 2013, 152, 276-89, PMID: 23273991 2. Peisley A*, Jo MH*, Lin C, Wu B, Orme-Johnson M, Walz T, Hohng S & Hur S. Kinetic Mechanism for Viral dsRNA Length Discrimination by MDA5 filament. Proc. Natl. Acad. Sci. U.S.A. (2012), 109, E3340-9, PMID:23129641 (* equal contribution) 3. Peisley A, Lin C, Wu B, Orme-Johnson M, Liu M, Walz T & Hur S. Cooperative Assembly and Dynamic Disassembly of MDA5 Filaments for Viral dsRNA Recognition. Proc. Natl. Acad. Sci. U.S.A. (2011), 108, 21010-5.
