Dear all, Is there a documented case of a structure determination from a hollow crystal? We have the unfortunate situation that a protein only crystallizes as a hollow tube, where the inside is filled with solvent, which ruins the diffraction patterns.
I was often confronted with similar situations, but in the previous cases I could always find a suitable crystal (part) or a different crystallization condition saved me. If anybody had general advise on how to proceed or could point me to relevant literature it would be much appreciated. With best regards Eike
