Dear fellow crystallographers, very much related to the recent discussion on the science behind crystallisation, we bring to your attention a Special Issue on "NOVEL STRATEGIES FOR IMPROVED PROTEIN CRYSTALLIZATION” from the MDPI journal Crystals: https://www.mdpi.com/journal/crystals/special_issues/novel_protein
This is a great opportunity to gather the expertises from many of you that have worked on unconventional crystallisation methods and/or in the theory behind these crystallisation methods. Short reviews or new research articles are welcome. Due to the open access policy, the journal charges publication fees, but, please, contact us directly for the chance to get a 20% discount grant. The deadline for submissions is 31st December 2019. We're putting a great effort in gathering scientific testimonies of research in this field (and we’re glad that some colleagues of this bb have already agreed to collaborate - thank you!). Our apologies for using this BB for advertising this Issue and thanks for any attention this may deserve. Best wishes, Maria João Romão Ana Luísa Carvalho Watch out for this Special Issue from Crystals! The Call for Papers <https://www.mdpi.com/journal/crystals/special_issues/novel_protein> is open. Research Assistant Professor at UCIBIO@FCT-NOVA *************************************************************************** Biologia Estrutural - Cristalografia de Raios-X (Gab 6.34) Dep. Quimica, FCT-UNL 2829-516 Caparica Portugal Phone: 00351212948300 (ext: Gab: 10940; Lab: 10962; X-ray Lab: 10915) Fax: 00351212948550 http://docentes.fct.unl.pt/almc <http://docentes.fct.unl.pt/almc> http://sites.fct.unl.pt/xtal <http://sites.fct.unl.pt/xtal> https://www.facebook.com/XtalNOVA *************************************************************************** > On 24 Jul 2019, at 11:00, Hargreaves, David > <david.hargrea...@astrazeneca.com> wrote: > > Dear CCP4bb, > > From my industrial perspective: The crystallisation bottleneck has probably > been fairly well addressed. High throughput screening using robotics and > around 20ul of protein per screen is common. There are lots of screens to try > even if they are rather redundant in their content. However, I feel there are > two things missing: high throughput protein production at microscale and > specific tools for construct design. Generally, industry is interested in the > druggable site which perhaps is only one domain of a multidomain target > protein. Getting a suitably robust crystal system often requires more than > one iteration of multiple construct design which in my experience is > something of a lottery. Some helpful design tools and an order of magnitude > increase in the number of constructs that can be delivered from protein > supply would help. > > Best wishes, > > David > > > Dr. David Hargreaves > Associate Principal Scientist > _____________________________________________________________________ > AstraZeneca > Discovery Sciences, Structure & Biophysics > Dr David Hargreaves. > Office R1-09/Lab FL54 > AstraZeneca Darwin Building > Unit 310 > Cambridge Science Park > Milton Road > Cambridge > CB4 0WG > > telephone: +441223223546 > > David.Hargreaves @astrazeneca.com > > Please consider the environment before printing this e-mail > > ________________________________ > > > AstraZeneca UK Limited is a company incorporated in England and Wales with > registered number:03674842 and its registered office at 1 Francis Crick > Avenue, Cambridge Biomedical Campus, Cambridge, CB2 0AA. > > This e-mail and its attachments are intended for the above named recipient > only and may contain confidential and privileged information. If they have > come to you in error, you must not copy or show them to anyone; instead, > please reply to this e-mail, highlighting the error to the sender and then > immediately delete the message. For information about how AstraZeneca UK > Limited and its affiliates may process information, personal data and monitor > communications, please see our privacy notice at > www.astrazeneca.com<https://www.astrazeneca.com> > > ######################################################################## > > To unsubscribe from the CCP4BB list, click the following link: > https://www.jiscmail.ac.uk/cgi-bin/webadmin?SUBED1=CCP4BB&A=1 ######################################################################## To unsubscribe from the CCP4BB list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/webadmin?SUBED1=CCP4BB&A=1
