Hi Rajnandani,

I’m happy to help you with questions about moonlighting proteins.  My lab 
created the MoonProt Database 
(moonlightingproteins.org<http://moonlightingproteins.org>).

I think you’re asking about 2 proteins with a similar fold having similar but 
not exactly the same functions - yes, that does occur.

Best regards,
Connie Jeffery

On Feb 2, 2020, at 4:28 AM, Rajnandani Kashyap 
<kashyap.rajnand...@gmail.com<mailto:kashyap.rajnand...@gmail.com>> wrote:

Dear All

I am curious to know about the promiscuous activity of a protein based on their 
fold. Can a protein having same fold also have same function (say not 100% but 
some activity) as the homologous structure.

Please also let me know few relevant PDB structures where such kind of activity 
is shown promising.


Regards

Rajnandani Kashyap
PhD Student


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