Hi, We have implemented a method for comparing cryoEM maps which works by scaling the maps based on resolution dependent amplitude fall-offs. The approach is discussed here: Joseph AP, Lagerstedt I, Jakobi A, Burnley T, Patwardhan A, Topf M, Winn M. Comparing Cryo-EM Reconstructions and Validating Atomic Model Fit Using Difference Maps. J Chem Inf Model. 2020 Feb 11. doi: 10.1021/acs.jcim.9b01103 The method is implemented as a task (TEMPy:Diffmap) in the CCP-EM software suite. The latests nighly builds also include options for global or local scaling of the maps. The global scaling option might be of interest to you if you are looking to scale and compare xtal maps.
Regards, Agnel ######################################################################## To unsubscribe from the CCP4BB list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/webadmin?SUBED1=CCP4BB&A=1
