The “something” is what gives them their edge (and which they’ve hinted at, but avoided being explicit)…
The main quality score used to distinguish their results is GDT_TS (Global Distance Test - Total Score - you can look it up on Wikipedia like I did). Although it doesn’t say in Wikipedia, it seems to be normalised to 100 for a perfect fit. Alphafold2 was scoring >90+, the best second-placed were ~60-65. Some of the superpositions of models from structure solution and AlphaFold2 looked like the errors in position of main and side chains were <<1Å. Since I’m quite new to the field, and haven’t really paid CASP much attention in the past I wouldn’t want to comment about past methods. I’ve got a lot to learn. Harry > On 9 Dec 2020, at 12:35, Bryan Lepore <bryanlep...@gmail.com> wrote: > > On Dec 9, 2020, at 07:16, Harry Powell wrote: >> >> ...the important thing is [...] they’ve done something that no-one else has >> managed to do as well in spite of years of trying. > > What, precisely, is the “something”? > > Exactly how much better than second place? > > Was the scoring the same across all years when no-one else managed to do as > well? > > -Bryan W. Lepore > > ######################################################################## > > To unsubscribe from the CCP4BB list, click the following link: > https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB&A=1 > > This message was issued to members of www.jiscmail.ac.uk/CCP4BB, a mailing > list hosted by www.jiscmail.ac.uk, terms & conditions are available at > https://www.jiscmail.ac.uk/policyandsecurity/ ######################################################################## To unsubscribe from the CCP4BB list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB&A=1 This message was issued to members of www.jiscmail.ac.uk/CCP4BB, a mailing list hosted by www.jiscmail.ac.uk, terms & conditions are available at https://www.jiscmail.ac.uk/policyandsecurity/
