Hi, it may be oxidized cysteine. Look here: https://www.researchgate.net/publication/44656220_Protein_S-thiolation_by_glutathionylspermidine_Gsp_The_role_of_Escherichia_coli_Gsp_synthetASEamidase_in_redox_regulation
and here: Trundle D, Cunningham LW. Iodine oxidation of the sulfhydryl groups of creatine kinase. Biochemistry. 1969;8:1919–1925. Best Michal czw., 17 mar 2022 o 18:37 Mohd Syed Ahangar <mohdsye...@gmail.com> napisał(a): > Hi CCP4BB members. > > I have been doing some protein crystal soaking with some covalently > binding fragments and in one structure I have got an extra density on > Cysteine but that density doesn't match with the expected fragment. The > fragment was in the form of iodide salt. when I fit the Iodine in the > density, it fitted fairly well than any other possible chemical entity. > From the density map it looks like something is covalently bound to > Cysteine. > Now my question is, can a sulphur atom of Cysteine have such an > interaction with Iodine. The distance between S and Iodine is 2.76A in this > case as shown in the attached figure. > I would be grateful if someone can shed some light on this. > > Thank you in advance. > -- > > Dr. Mohd Syed Ahanger, > > Faculty of Biological Sciences, > > University of Leeds, Leeds, UK. > > ------------------------------ > > To unsubscribe from the CCP4BB list, click the following link: > https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB&A=1 > ######################################################################## To unsubscribe from the CCP4BB list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB&A=1 This message was issued to members of www.jiscmail.ac.uk/CCP4BB, a mailing list hosted by www.jiscmail.ac.uk, terms & conditions are available at https://www.jiscmail.ac.uk/policyandsecurity/
