Dear Colleagues,

A postdoctoral position is immediately available for a highly motivated 
individual interested in elucidating molecular mechanisms of ubiquitin 
signaling and DNA repair.  Research is focused on the enzymatic machinery 
responsible for protein ubiquitination and large protein complexes involved in 
regulating DNA repair and immunity.  These issues will be addressed using a 
multidisciplinary approach that includes cryo-EM and X-ray crystallography, 
complemented with biochemical/biophysical techniques and cell-based assays.

Successful candidates will join the vibrant scientific community at UT Health 
San Antonio and enjoy abundant access to state-of-the-art cryo-EM 
instrumentation including a Glacios TEM equipped with a Falcon 4 direct 
electron detector and Selectris Imaging Filter that are the centerpiece of our 
brand new cryo-EM facility.  Access to outstanding X-ray crystallography and 
NMR resources are also available.

Candidates should hold a recently obtained PhD in biochemistry, chemistry, or 
related subject.  Demonstrated expertise in cryo-EM is highly desirable, though 
individuals with expertise in protein chemistry, and/or the biochemical 
analysis of protein ubiquitination and/or DNA repair will also be considered.  
Experience with protein expression in insect and mammalian cells is a plus.

Recent publications highlighting our research interests:
*Structural insights into BCDX2 complex function in homologous recombination 
[https://www.nature.com/articles/s41586-023-06219-w]
*Cryo-EM structures of Uba7 reveal the molecular basis for ISG15 activation and 
E1-E2 thioester transfer [https://www.nature.com/articles/s41467-023-39780-z]
*Crystal structures reveal catalytic and regulatory mechanisms of the 
dual-specificity ubiquitin/FAT10 E1 enzyme Uba6 
[https://www.nature.com/articles/s41467-022-32613-5]
*Activity profiling and crystal structures of inhibitor-bound SARS-CoV-2 
papain-like protease: A framework for anti-COVID-19 drug design 
[https://www.science.org/doi/10.1126/sciadv.abd4596]

Interested candidates should e-mail a cover letter, CV, and the names of three 
references to: ols...@uthscsa.edu.

Best,

-Shaun

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