I used it for PPI prediction of a mAb and our target protein and it was surprisingly accurate compared to our crystal structure. Binding of the mAb was <0.5 rmsd I was stunned.
Jürgen P.S. paper should be accepted soon, but you’ll find a current version on BioRxiv if you are interested. AF3 is not part of the paper though. But that’s what I used for benchmarking since the coordinates have not been released yet __________________________________________ Jürgen Bosch, PhD, MBA Center for Global Health & Diseases Case Western Reserve University https://www.linkedin.com/in/jubosch/ CEO & Co-Founder at InterRayBio, LLC On Oct 5, 2024, at 08:48, Jon Cooper < 0000488a26d62010-dmarc-requ...@jiscmail.ac.uk> wrote: Just wondering if anyone has any comments on, or concrete experiences with, alphafold3. I might try to cobble something together for Crystallography News (he says, having missed the main Nature paper, ahem). My googling has only given me hype and gripe so far ;-0 ;-0 Best wishes, Jon Cooper. jon.b.coo...@protonmail.com Sent from Proton Mail Android ######################################################################## To unsubscribe from the CCP4BB list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB&A=1 This message was issued to members of www.jiscmail.ac.uk/CCP4BB, a mailing list hosted by www.jiscmail.ac.uk, terms & conditions are available at https://www.jiscmail.ac.uk/policyandsecurity/ ######################################################################## To unsubscribe from the CCP4BB list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB&A=1 This message was issued to members of www.jiscmail.ac.uk/CCP4BB, a mailing list hosted by www.jiscmail.ac.uk, terms & conditions are available at https://www.jiscmail.ac.uk/policyandsecurity/
