Hello,
I would like to take this opportunity to announce the release of our new
web-tool, FoldScript (https://foldscript.ibcp.fr/), which complements
our web-tool ESPript.
FoldScript allows to analyze and to filter with experimental results (ie
residues known to be involved in intermolecular interfaces) the list of
AI-models generated by Alphafold3 (currently 5 models versus 25 with
Alphafold-Multimers). We created this web-service because we observed
that the top-ranked model supplied by AF3 is not necessarily the most
“relevant” one, and we wanted to quickly compare models supplied by AF3,
Alphafold-multimer, EMSfold, Rosettafold... As has been related by
others, we observe that AI-predicted hetero-oligomeric structures have
to be taken with caution.
Best
patrice
Le 2024-10-05 15:48, Jon Cooper a écrit :
L'adresse mail de l'expéditeur est extérieure :
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Just wondering if anyone has any comments on, or concrete experiences
with, alphafold3. I might try to cobble something together for
Crystallography News (he says, having missed the main Nature paper,
ahem). My googling has only given me hype and gripe so far ;-0 ;-0
Best wishes, Jon Cooper.
jon.b.coo...@protonmail.com
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