Hi all, I would like to remind you that our next industry talk will be coming soon on 14 January 2026 at 2 pm UK time. The speaker is Valerie Pye from Sygnature Discovery. This online talk will be via Teams (note the change from previous events via Zoom). Registration is free but required to get the webinar link: https://events.teams.microsoft.com/event/db9fb1f8-20be-4e09-9cc5-7a1527eff25f@3f66361c-a87e-4158-8f61-99e82db3cac8
Title: Introduction to Cryo-EM for Computational Chemists Abstract: Understanding macromolecular structure is fundamental to modern drug discovery. Structural insights reveal how proteins and/or nucleic acids interact with ligands, and/or other proteins enabling rational design of therapeutics with improved potency and selectivity. Electron cryomicroscopy (cryo-EM) has emerged as a transformative technique, complementing traditional X-ray crystallography by providing high-resolution structures of complex and dynamic systems that can often defy crystallisation. This presentation will introduce the use of cryo-EM for single particle analysis, outline the workflow from sample preparation to 3D reconstruction and interpretation, and highlight key considerations when using cryo-EM data for drug development—such as local vs global resolution, conformational variability, and ligand validation. The application of cryo-EM to challenging targets, including membrane proteins and large assemblies, showcases its growing importance in structure-based drug design. Please feel free to share this with anyone who might be interested. Best wishes, Sarah ######################################################################## To unsubscribe from the CCP4BB list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB&A=1 This message was issued to members of www.jiscmail.ac.uk/CCP4BB, a mailing list hosted by www.jiscmail.ac.uk, terms & conditions are available at https://www.jiscmail.ac.uk/policyandsecurity/
