I believe I traced my neighbor loss to a problem with the IOS. I had 12.1.3 EA running when I had the OSPF neighbor loss problem. I upgraded it to 12.2.7 and the router held neighbors and routes all day yesterday. It may have been compounded by a possible backplane issue, but that would not seem to account for the fact that it dropped the connection after 15 - 20 minutes after resetting the interface not shutting the router off completely. I don't know if this is applicable to your case or not, and I know it's non-trivial to change IOS on a production network to play with it.
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