Title: Message
I'm sorry to hear about this disappointing news. I just want to mention that you may want to explore getting your son tested for mutations resistant to Gleevec; you didn't mention doing this so just wanted to point it out as a rational move right now and maybe should be an additional first step along with a dosage increase. You don't want to wait around doing 800 mg only to find out he's developed resistance to Gleevec and time has been wasted.
 
Best of luck, and keep us posted.
 
jennifer g.
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-----Original Message-----
From: Allen & Gail Lefebvre [mailto:[EMAIL PROTECTED]
Sent: Tuesday, September 28, 2004 12:31 AM
To: CML Yahoo Group
Subject: [CML] Cytogenics vs FISH


We are still assessing options but it  looks likely that the first step
will be increased dosage of IM (he is on 400 now).  The one wrinkle
appears to be the possible removal from the study protocol, as it seems
there is no allowance for dose variation in the study and an exclusion
for 'progressive' disease if it reaches or exceeds 30% ph+.  Will have
to wait to see how they interpret that and what impact that may have.
 
 


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