It is common for some blood counts (especially WBC and Platelets) to
oscillate a bit during the first few months on Gleevec.  I assume your
wife is being tested every month at this stage, so you will be able to
track the blood counts.   The initial dose of Gleevec, whether 400,
600, or 800, is Dr.s' choice.  I'd say it is more usual to start on 400
because, the Dr.s sometimes want to see how well you handle the drug,
but there is a lot of evidence to suggest higher doses are more
effective.  You really aren't going to know for sure for several
months.

Since you are new here, I'll repeat my oft-repeated mantra again.  That
is, make sure that you have a Dr. that is a CML expert on your medical
team.

Mike Burwen


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