Cheryl, My son is taking imatinib and green tea capsules and is doing very well. Have you seen the article below? Could you please give us your comments about this article?
* ** http://www.ingentaconnect.com/content/bsc/cas/2009/00000100/00000002/art00023 * *Catechin, green tea component, causes caspase-independent necrosis-like cell death in chronic myelogenous leukemia **Authors: *Iwasaki, Reo; Ito, Kinji1<http://www.ingentaconnect.com/content/bsc/cas/2009/00000100/00000002/art00023#aff_1>; Ishida, Takaomi2<http://www.ingentaconnect.com/content/bsc/cas/2009/00000100/00000002/art00023#aff_2>; Hamanoue, Makoto3<http://www.ingentaconnect.com/content/bsc/cas/2009/00000100/00000002/art00023#aff_3>; Adachi, Souichi4<http://www.ingentaconnect.com/content/bsc/cas/2009/00000100/00000002/art00023#aff_4>; Watanabe, Toshiki2<http://www.ingentaconnect.com/content/bsc/cas/2009/00000100/00000002/art00023#aff_2>; Sato, Yuko5<http://www.ingentaconnect.com/content/bsc/cas/2009/00000100/00000002/art00023#aff_5> *Source:* Cancer Science<http://www.ingentaconnect.com/content/bsc/cas;jsessionid=r8wt4h2qn1iq.victoria>, Volume 100, Number 2, February 2009 , pp. 349-356(8) *Publisher: *Blackwell Publishing<http://www.ingentaconnect.com/content/bp;jsessionid=r8wt4h2qn1iq.victoria> *Abstract:* Management strategies of chronic phase chronic myelogenous leukemia (CML) have been revolutionized due to the discovery of a selective tyrosine kinase inhibitor, imatinib (Gleevec, STI571), which is substantially improving median survival. However, emergence of imatinib-resistance has put up a serious problem that requires novel treatment methods. Catechins, polyphenolic compounds in green tea, are gathering much attention due to their potential antitumor effects. So far (-)-epigallocatechin-3-gallate (EGCG), the most abundant component of catechin, has been shown to cause typical apoptosis in several tumor cell lines in most cases through activation of caspases. In this study, we showed that EGCG predominantly caused necrosis-like cell death via a caspase-independent mechanism in CML cells, K562 and C2F8, whereas imatinib induced the typical apoptotic cell death. Moreover, this caspase-independent cell death partially mediated the release of apoptosis-inducing factor, AIF, and serine protease, HtrA2/Omi, from the mitochondria to cytosol. In addition, EGCG enhanced the imatinib-induced cell death (*P <* 0.01) resulting in additive cell death in K562 cells and EGCG alone, effectively reduced the viability of imatinib-resistant K562 cells (*P <* 0.01). Catechin is a possible candidate for an antitumor agent that causes cell death in CML cells via a caspase-independent mechanism. (*Cancer Sci* 2009; 100: 349-356) On Tue, Jun 30, 2009 at 11:25 AM, cheryl.simon...@cmlsociety.org < cheryl.simon...@medsummit.com> wrote: > > Hi Jeannie, > > Stay away from the green tea and oolong tea. There is new information > that more than one small cup of these tea's a day can interfere with > the TKI's. Why? It seems that these tea's are such powerful > antioxidants that they work too well at removing "free radicals" in > the body. These free radicals/oxidants are part of the reactive > oxygen species, or better known as free radicals. We hear a lot about > how "free radicals" are bad and we need to increase our use of > antioxidants to get rid of them. However, our body also uses these > free radicals to kill cancer. The TKI's we take to treat our CML also > produce free radicals, that are used to kill CML cancer cells. So, if > we get rid of the free radicals, we block our body from producing them > and directly interfere with our bodies ability to attack them. This > was all very eloquently explained at a private meeting of the European > School of Hematology, last year which I was able to attend. > > There are a number of foods and drugs that can interfere in this way. > We have produced a food to drug interaction chart and will upload it > shortly on our website. This drug chart has been prepared with our > medical advisor's and reviewed by the medical department at both > Novartis and BMS. > > Jeannie, I hope all works out for you and hope you have no mutations > that have developed. > > Keep us posted. > > Best Regards, > Cheryl-Anne Simoneau, > President, The CML Society of Canada > > > > -- Ricardo --~--~---------~--~----~------------~-------~--~----~ [CMLHope] A support group of http://cmlhope.com ------------------------------------------------- You received this message because you are subscribed to the Google Groups "CMLHope" group. To post to this group, send email to CMLHope@googlegroups.com To unsubscribe from this group, send email to cmlhope-unsubscr...@googlegroups.com For more options, visit this group at http://groups.google.com/group/CMLHope -~----------~----~----~----~------~----~------~--~---
