Rien,
It would be best to wait for the next PCR result.  It could be
undetectable again.  But if it continues to rise, the mutation
analysis would be useful.  But approximately 30% of Gleevec failures
are due to other reasons, so it is not always the complete answer.  A
rising PCR would suggest the need to switch medications.  Increasing
from 600mg to 800mg would not likely be the right answer.  You would
benefit more from switching drugs.

Regarding the colon cleansing,  it would be best to irrigate within a
couple hours after taking Gleevec.  The previous dosage would be
mostly eliminated at that point, and the new dosage would not have
reached the colon by then.  You should avoid irrigating from 3 hours
to 18 hours after taking Gleevec.
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