-Caveat Lector-

Begin forwarded message:

From: "Sardar" <[EMAIL PROTECTED]>
Date: July 24, 2005 9:43:13 AM PDT
To: "Sardar" <[EMAIL PROTECTED]>
Subject: Fw: Press Notice: Wall Street Journal - Fluoride/Bone Cancer



----- Original Message -----
Sent: Friday, July 22, 2005 11:32 AM
Subject: Fw: Press Notice: Wall Street Journal - Fluoride/Bone Cancer




----- Original Message -----
From: "National Pure Water Association" <[EMAIL PROTECTED]>
Sent: Friday, July 22, 2005 5:35 PM
Subject: Press Notice: Wall Street Journal - Fluoride/Bone Cancer



WALL STREET JOURNAL ,
JULY 22, 2005.

Fluoridation, Cancer: Did Researchers Ask The Right Questions?
By Sharon Begley

WHEN HEALTH OFFICIALS decided to add fluoride to the water supply of

Grand

Rapids, Mich., in 1945, they plunged ahead despite the lack of a

rigorous,

large-scale study of the risks and benefits. And for most of the next 60
years, fluoridation research has gone pretty much like that. It has not
been science's finest hour.

Questions about fluoridation have returned with renewed vigor because of
allegations of scientific misconduct against a prominent researcher at

the

Harvard School of Dental Medicine. The Environmental Working Group, an
advocacy organization in Washington, charged last month that Chester
Douglass misrepresented an unpublished study about bone cancer and
fluoridated tap water. In written testimony to the National Research
Council last year, Dr. Douglass said he had found no evidence that
fluoridation increased risk of osteosarcoma, a rare bone cancer. But a
2001
study he cited, and oversaw, found that boys who drink fluoridated water
have a greater risk of developing the disease. (Dr. Douglass did not
respond to requests for comment.)

More interesting than what Dr. Douglass said or didn't say, however, is
the
study he swept under the rug. It was conducted by one of his doctoral
students, Elise Bassin. She started with the same raw data as her
mentor --
139 people with osteosarcoma and 280 healthy "controls" -- but saw a way
to
improve on it. Since most of the 400 people diagnosed in the U.S. each
year
with osteosarcoma are kids, and since any ill effect of fluoride would
likely come when bones are growing most quickly, she focused on the 91
patients who were under 20.

HER RESULT: Among boys drinking water with 30% to 99% of the fluoride
levels recommended by the U.S. Centers for Disease Control and

Prevention,

the risk of osteosarcoma was estimated to be five times as great as

among

boys drinking nonfluoridated water. At 100% or more, the risk was an
estimated seven times as high. The association was greatest for boys six
to
eight.

To be sure, one study proves nothing. Moreover, Dr. Bassin hasn't
published
her core findings (though in 2004 she and colleagues published a
description of their methodologies). As Boston University epidemiologist
Richard Clapp says, "Peer review picks up things that even doctoral
students at Harvard might miss."

So I asked scientists to read the study. BU's Kenneth Rothman, founding
editor of the journal Epidemiology, called it of "publishable quality."
Zeroing in on young patients, he said, was good science: "If there were

an

adverse effect of fluoride, it's possible an effect of early exposure
would
be manifest in the first 20 years of life - but not after." Looking at

all

ages, in other words, could conceal any link between fluoridation and
cancer.

Besides focusing on kids, Dr. Bassin and her colleagues found out where
each cancer patient ever lived, and what kind of water they drank when.
Other studies have just noted what water a patient was drinking at the
time
of diagnosis. The problem with that is, you risk classifying someone as
drinking nonfluoridated water who in fact drank fluoridated water when

it

mattered -- in childhood. The result is that the osteosarcoma rates of
people drinking fluoridated water might look no different from those of
people drinking nonfluoridated. "She did great shoe-leather

epidemiology,"

says William Maas, head of oral health at the CDC and a supporter of
fluoridation.

PREVIOUS STUDIES have been contradictory. A 1991 animal study by the
National Toxicology Program concluded that fluoride might raise the risk
of
osteosarcoma, but only in male rats, not female. Also in 1991, a

scientist

at the National Cancer Institute found "an unexplained increase" in
osteosarcoma in men under 20 in fluoridated communities. Most human
studies, though, provide "no credible evidence for an association

between

fluoride in drinking water and the risk of cancer," said a 1993 NRC
report.

But when you look carefully at the negative studies, you have to wonder.
Some investigated a link to all cancers; because osteosarcoma is rare,

an

increase would be unlikely to show up in that vast sea. Other studies

were

tiny, or included adults as old as 84, which would wash out effects that
target kids. Most categorized osteosarcoma patients as drinking
fluoridated
or nonfluoridated water based on where they lived at diagnosis, not as
kids. Concerned about such lapses, the NRC report called the studies "of
limited sensitivity."

Even if fluoridation causes just a few hundred cases of osteosarcoma

every

year, does the public health benefit justify that risk? "When we started
fluoridating water, we thought to get the benefits it would have to get
incorporated into the enamel before the tooth erupted," which happens

only

if you swallow it, says the CDC's Dr. Maas. But that turns out not to be
so. Topical fluoride, as in gels and toothpaste, works at least as well.

Most proponents now say fluoridation cuts the rate of tooth decay 18% to
25%. How much is that? Less than one tooth surface. "The absolute impact
of
18% or even 25% is low," says Stephen Levy of the University of Iowa,

who

supports fluoridation.

The next authoritative report on fluoridation will be the NRC's. One
scientist close to the committee thinks it may be released this fall,
months later than expected. "We thought this was going to be routine,"

he

says. "It wasn't." With fluoridation, it seldom is.
************************

George Glasser
Water Quality Advisor
National Pure Water Association




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