-Caveat Lector-

Ominous new class of virus. Real virus not computer virus.
flw

> STEALTH VIRUS; VITERIA & HUMAN DISEASE
> **************************************
> A ProMED-mail post
> <http://www.healthnet.org/programs/promed.html>
>
> Date: Date: Thu, 1 Jul 1999 13:00:10 -0700
> From: W. John Martin
>
>
> I would like to increase awareness of the sequence data obtained from an
> atypically structured African green monkey simian cytomegalovirus-derived
> "stealth virus." Three publications on this virus appeared in the April
> 1999 issue of Experimental and Molecular Pathology. Copies of the
articles
> are posted on the Web Site <http://www.ccid.org>. An additional paper in
> this journal describes a stealth virus infected child with a spongiform
> encephalopathy.
>
> Brief summaries:
>
> Stealth Adaptation of an African Green Monkey Simian Cytomegalovirus.
The
> prototype stealth virus lacks specific genes coding for the major
antigenic
> targets recognized by anti-CMV cytotoxic T lymphocytes. It is
> unquestionable that the virus came from an African green monkey simian
> cytomegalovirus.
>
> Bacterial-Related Sequences in a Simian Cytomegalovirus-Derived Stealth
> Virus Culture. The stealth adapted virus retains and/or regains its
> cytotoxic activity by assimilating additional genes that can come from
> cellular sequences, and also from bacterial sequences. The recombination
of
> viral and bacterial sequences has not been previously described. The term
> "viteria" has been coined for such organisms. This can explain aspects of
> stealth virus biology and transmission.
>
> Melanoma Growth Stimulatory Activity (MGSA/GRO-alpha) Chemokine Genes
> Incorporated into an African Green Monkey Simian Cytomegalovirus-Derived
> Stealth Virus. Stealth viruses have the capacity to assimilate cellular
> genes including genes with potential cancer causing capacity. An example
is
> provided in which 3 copies of an MGSA-related gene have been incorporated
> adjacent to a region of the SCMV-derived stealth virus containing UL141,
> UL144 and UL145 genes.
>
> Stealth Virus Epidemic in the Mohave Valley: Severe Vacuolating
> Encephalopathy in a Child Presenting with a Behavioral Disorder. This is
a
> clinical paper showing that one can be stealth virally infected yet not
> show clinical signs on regular neurological examination. This is
> demonstrated by the case of an 8 year old child infected by the stealth
> virus and originally thought to have had a behavioral problem. The child
> lives in an area of the USA experiencing an outbreak of chronic disabling
> illnesses attributed to stealth viral infections.

> --> W. John Martin, M.D., Ph.D.
>
> [Fascinating find.  Newly discovered virus, newly coined word, perhaps
even
> some new thinking required. - Mod.CHC]

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