-Caveat Lector-   <A HREF="http://www.ctrl.org/">
</A> -Cui Bono?-

  Return of the killer virus that spread terror in New York

Robin McKie and Ed Vulliamy
Sunday March 19, 2000

It was the news that researchers were dreading. A dead red-tailed hawk, found
in Bronxville, a suburb of New York, was last week found to be carrying the
fatal West Nile virus that terrorised the city last year. Now the entire East
and Gulf coasts of the United States are braced for the imminent return of a
mysterious killer which may strike with enhanced ferocity.
'It's time. The virus is out there,' said pathologist Ward Stone as he
emerged from a sealed laboratory where he had examined the hawk. West Nile
encephalitis's first dramatic appearance in the Western hemisphere - in a
cluster of cases in Queens, New York - sent the city into a frenzy in August.
Helicopters sprayed entire neighbourhoods with disinfectant after the disease
killed horses, thousands of birds and several people. Symptoms began with
flu-like shivers and were followed by fever, disorientation and brain
swelling that led to death in seven out of the 62 cases of people affected by
the virus.

Scientists at the Center for Disease Control (CDC) in Atlanta, Georgia, had
hoped the illness - spread by mosquitoes from birds to humans - would die out
over winter. Now their hopes have been dashed. Apart from the hawk,
mosquitoes hibernating in underground rooms beneath the historic Fort Totten
district of Queens have been found to be virus-positive. As America's East
Coast begins to warm, mosquitoes carrying the West Nile killer are expected
to spread further than last year. As Nicholas Kramer of the CDC said: 'The
virus is still here and there is a good chance it will amplify this summer.'

Warning circulars have been posted to all New York doctors and emergency
instructions for citizens are being drafted, while it has been decreed that
all dead birds must be handed in to health authorities. This weekend a sad
stream of dead birds was being directed to New York state pathology
laboratories.

What really alarms American health officials is the danger of the disease
establishing itself permanently in the country. But what will happen if
migrating birds have already begun to spread West Nile across eastern
America? The next months will be the 'test of how long-lasting or fleeting'
West Nile is in the US, said Dr Roger Nasei, of the CDC.

Californian expert Ian Lipkin said last week 'there is definitely a cause for
concern'. But his fears were countered by CDC expert Duane Gubler, who said
it was still possible this year's outbreak could be contained. The species of
mosquito most closely linked to the virus does not emerge until later in the
spring when a mass spraying campaign begins.

The aim will be to eliminate larvae and breeding sites. Property owners will
be told to unclog roof gutters, empty or chlorinate swimming pools, and throw
away old tyres and buckets.

A more worrying prospect has been raised by virologists in Britain. West Nile
disease is closely related to the illness St Louis encephalitis, which is
fairly common in America. That raises the fear that people already infected
with the latter may become especially vulnerable to West Nile disease.

'There is a process called antibody dependent enhancement,' said Dr Ernie
Gould, deputy director of the Institute of Virology and Environmental
Microbiology in Oxford. 'We have observed it in other diseases, and I believe
it could happen with West Nile.'

In short, America faces the threat of a deadly new epidemic. The next few
months will determine how serious that danger is.

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