-Caveat Lector-

On 22 Jun 01, at 21:04, Bill Howard wrote:

> << Maybe it is a liberal/commie, econazi food, Bill? >>
>
> Could be, could be. My mother (Yes, I did have a mother.) told me when I was
> a young'n, real red blooded american men eat meat.

Sometimes mothers make mistakes. --SW

Study links red meat to colon cancer



By EMMA ROSS, Associated Press

LYON, France (June 23, 2001 3:43 p.m. EDT) - Eating red meat may
create about as much of a certain cancer-promoting chemical in the colon
as smoking does, new research indicates.

The findings, presented Saturday in Lyon at the European Conference on
Nutrition and Cancer, were part of a study that also appears to revive the
theory that fiber wards off colon cancer, the second most deadly cancer
worldwide.

The idea that a high-fiber diet rich in fruits, vegetables and grains prevents
colon cancer suffered a setback last year after two studies failed to find an
effect.

But the latest research, which experts say is the most reliable to date on the
link between eating habits and cancer, found that those who ate a high-
fiber diet had 40 percent less chance of developing colon cancer than
those who ate the least roughage.

The study, which involved 406,323 people from nine European countries,
had the widest range in fiber intake of any study to date.

At the start of the study, in 1993, questionnaires separated the people into
five categories, according to how much fiber they ate. The top and bottom
1 percent were excluded to eliminate extremes. There were about 80,000
people in each of the remaining categories.

There were 176 colon cancer diagnoses in the group who ate the least
fiber and 124 cases in the group that ate the most - a difference of 40
percent.

The finding redeems fiber as a potential anti-cancer agent, said Nicholas
Day, a cancer expert at Cambridge University in England. Day was not
involved in the fiber investigation.

Day has criticized previous studies on nutrition and cancer. He says they
were too small, were limited to one country at a time, included narrow
ranges in eating patterns and did not measure precisely enough to detect
the effect of small differences in nutrition.

Dr. Anthony Miller, a professor at the German Cancer Research Center
who was not involved in the study, agreed.

"I think this study shows things are beginning to come together," Miller said.
"The (American) studies, the way they measured everything was not very
good."

Scientists believe that bacteria in the colon ferment fiber and in the process
create a by-product called butyrate. Experts believe that cells in the lining of
the colon turn cancerous when normal cell death is hampered. Test-tube
studies have shown that butyrate is a potent inducer of cell death.

Those who don't eat a lot of fiber tend to load up on protein, which also
provides food for bacteria in the colon, said Dr. Sheila Bingham, deputy
director of the Human Nutrition Unit at Cambridge University, who led both
studies.

Lab tests have shown that the combination of red meat and colon bacteria
produces chemicals called N-Nitroso compounds, some of which are
cancerous, Bingham said.

One of them, known as NNK, is found in tobacco smoke.

In the meat experiment, volunteers moved into a laboratory for at least three
months and their diets were manipulated. Cells from the lining of the colon
that were shed during defecation were examined to see the effect of the
dietary changes.

Everyone was put on the same regime. Calories, fat and weight were kept
the same throughout, but the amounts and types of protein changed.

The more red meat eaten, the higher the concentration of N-Nitroso in the
feces.

"In fact, at the high level of red meat consumption, the level of N-Nitroso
compounds which were present in the fecal material was equivalent to the
concentration that is found in tobacco smoke," Bingham said.

The most red meat the scientists gave the volunteers was 420 grams (15
ounces) per day.

Replacing the red meat with the same amount of chicken or fish resulted in
a drop in the N-Nitroso compounds back to normal. They stayed at that
level when the protein came from dairy or soy products.

"The only difference between red and white meat is the amount of heam
they contain," Bingham said. Red meat is rich in heam, a part of the blood
that contains the iron that gives the meat its red color.

When the volunteers were fed a diet low in red meat but with supplements
of heam iron, the levels of N-Nitroso in the feces rose again.

Experts say the results are consistent with other evidence presented at the
meeting Friday, which indicated that preserved meats increase the risk of
colon cancer, but that fresh red meat may not.

Preserved meat, which includes bacon, cured ham, salami, corned beef
and pastrami, has much more heam than fresh meat such as steak or lamb
chops.

There is no proof that N-Nitroso compounds in the colon are toxic, but the
circumstantial evidence is strong that it might be, experts said.

"Some of these compounds are very carcinogenic ... in other species, and
humans have the same enzymes which are required to metabolize them, so
really it's a logical thing," Day said.


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