-Caveat Lector-

~~for educational purposes only~~
[Title 17 U.S.C. section 107]

Children's drug is more potent than cocaine
Jean West

The children's drug Ritalin has a more potent effect on
the brain than cocaine, a study has found.

Using brain imaging, scientists have found that, in pill
form, Ritalin - taken by thousands of British children
and four million in the United States - occupies more
of the neural transporters responsible for the 'high'
experienced by addicts than smoked or injected
cocaine. The research may alarm parents whose
children have been prescribed Ritalin as a solution to
Attention Deficit Hyperactive Disorder.

The study was commissioned to understand more
about why Ritalin - which has the same
pharmacological profile as cocaine - is effective in
calming children and helping them concentrate, while
cocaine produces an intense 'high' and is powerfully
addictive.

In oral form, Ritalin did not induce this intense
psychological 'hit'. But Dr Nora Volkow, psychiatrist
and imaging expert at Brookhaven National
Laboratory, in Upton, New York, who led the study,
said that injected into the veins as a liquid rather than
taken as a pill, it produced a rush that 'addicts like
very much'. Interviewed in last week's Journal of the
American Medical Association newsletter, she said:
'They say it's like cocaine.'

Even in pill form, Ritalin blocked far more of the brain
transporters that affect mood change and had a
greater potency in the brain than cocaine.
Researchers were shocked by this finding. A normal
dose administered to children blocked 70 per cent of
the dopamine transporters. 'The data clearly show the
notion that Ritalin is a weak stimulant is completely
incorrect,' said Volkow. Cocaine is known to block
around 50 per cent of these transporters, leaving a
surfeit of dopamine in the system, which is
responsible for the hit addicts crave. But now it is
known that Ritalin blocks 20 per cent more of these
auto-receptors.

'I've been almost obsessed about trying to understand
[Ritalin] with imaging,' said Volkow. 'As a psychiatrist I
sometimes feel embarrassed [about the lack of
knowledge] because this is by far the drug we
prescribe most frequently to children.'

However, it was still not clear why a drug that has
been administered for more than 40 years was not
producing an army of addicted schoolchildren. Volkow
and her team concluded that this was due to the much
slower process of oral ingestion. It takes around an
hour for Ritalin in pill form to raise dopamine levels in
the brain. Smoked or injected, cocaine does this in
seconds.

Dr Joanna Fowler, who worked with Volkow on the
project, said: 'All drugs that are abused by humans
release large quantities of dopamine. But dopamine
is also necessary for people to be able to pay
attention and filter out other distractions.'

But opponents of Ritalin, labelled a 'wonder drug' and
a 'chemical cosh', believe it may be addictive and has
dangerous side-effects. Moreover, many believe
ADHD is a fraudulent title for a non-existent condition
once put down to the exuberance of youth. Professor
Steve Baldwin, a child psychologist from Teesside
University, who died this year in the Selby rail crash,
campaigned against Ritalin. He pointed out
similarities between the drug and amphetamines as
well as cocaine.

Mandy Smith of Banff in Scotland has a son of eight
who was prescribed Ritalin for nine months. 'I am
astonished the British Government have allowed this
drug to be prescribed,' she said. 'It can destroy
people's lives. My son was a changed person when
he took Ritalin. He was suicidal and depressed.'

Janice Hill, of the Overload Support Network, a charity
for parents of children with behavioural problems,
said: 'Now we have thousands of children in Scotland
taking a drug that is more potent than cocaine. What
does it take before the situation is thoroughly
investigated?'

A spokeswoman for Novartis, which makes Ritalin,
said: 'Ritalin is available as tablets only. It should only
be initially prescribed by a doctor who is a specialist
in child behavioural disorders and should always be
used and monitored under strict medical supervision.'

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