Well I think I found the culprit.  I knew it must be something simple.  And it 
was.
Our pydisutils.cfg had both a index-url and find_links, both with the same 
simple url.
When I removed the find_links, all the time sinks went away.  What did take 3hr 
is now back to 24min.  /facepalm

fwiw, this is just a python setup.py test, and uses tox virtualenv setuptools.  
I also thought that setuptools just used pip, but now I see it's actually 
easy-install, which I didn't realize was a different thing from pip.
Good luck on https://github.com/pypa/setuptools/issues/917
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