>From my personal experience:

   - make frontend (angular) almost 100% separate from backend (django)
   - if you want to build truly restful service, avoid DRF (more precisely 
   -- avoid whole "magical" model views, which implements CRUD antipattern)
   - focus on hypermedia (i.e. use Hydra, or start with something custom -- 
   going restful is a process)
   - avoid django forms if possible (use Colander, for example)

 
DRF will give you big community, rich features, more skilled devs and rapid 
developemnt (especially at the initial stage), but later it may introduce 
limitations. 
Just my 5 cents.

Marcin

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