Chris,
Hi. It's good that they have new studies confirming this stuff, but
the looping of DNA into 3D structures inside the nucleus has been known
for awhile. I think they're even starting to map these interactions just
like the human genome project. One of the methods they use is to crosslink
the DNA in the nucleus so that the shape it's currently in is saved, and
then sequence the crosslinked areas to identify the crosslinked segments of
DNA. But, I admit calling this a wormhole is kind of just good marketing.
I guess the everything list is kind of like a wormhole that brings
together distant people so they can talk about "everything"! :-)
Also, on the epigenetic inheritance thing via histones, it's also good
that new studies are proving this stuff, but epigenetic changes (changes in
gene expression caused by things other than changes to the DNA sequence)
that can be inherited have also been known for 10 years or so. So far,
what they know are that these changes are caused by adding or removing
methyl groups to the DNA bases or methyl and acetyl groups to the histones.
That affects how the genes are expressed. These changes can be affected
by the environment and your own activities (like exercise). So, your
descendants may thank you for exercising and eating right!
The only reason I know some stuff about this is that I have kind of a
weird job where I read biochem. articles all day and put the new stuff into
a database.
See you!
Roger
On Saturday, April 4, 2015 at 3:08:19 PM UTC-4, cdemorsella wrote:
>
>
>
> -----Original Message-----
> From: everyth...@googlegroups.com <javascript:> [mailto:
> everyth...@googlegroups.com <javascript:>] On Behalf Of Russell Standish
> Sent: Thursday, February 26, 2015 1:44 PM
> To: 'Chris de Morsella' via Everything List
> Subject: Re: DNA Wormholes can cause cancer (what!?)
>
> Of course, this is what Australia's John Mattick has been saying for
> decades (I heard him talk on this nearly 15 years ago, for instance, and
> he'd been railing at the establishment sometime before that).
>
> >> But "wormholes"? Really? Someone in marketing has been given far too
> liberal a rein.
>
> They're always on the hunt for that catchy title aren't they; I find them
> amusing :)
> Still, in seriousness, it's an interesting idea: that previously
> overlooked, non-local effects, naturally operating within an organisms DNA
> may be playing a more fundamental role in life than previously believed (or
> even considered to be occurring at all)
> Chris
>
> Cheers
>
>
> On Thu, Feb 26, 2015 at 05:26:16PM +0000, 'Chris de Morsella' via
> Everything List wrote:
> > [Have been very busy on a new software project and have not had time
> > to follow and participate on this list... such an active list :). ]
> > Came across this article and found it interesting also from an
> > information science point of view -- taking the perspective of DNA
> > being a fairly dynamic information repository. It seems like the
> > butterfly effect is operating in DNA... a small difference one place
> > can result in effects being triggered in very distant DNA locations...
> > or as the researchers said... kind of like a wormhole.-Chris
> >
> > Cancer risk linked to DNA ‘wormholes’
> >
> > February 25, 2015
> > Single-letter genetic variations within parts of the genome once
> dismissed as “junk DNA” can increase cancer risk through remote effects on
> far-off genes, new research by scientists at The Institute of Cancer
> Research, London shows.The researchers found that DNA sequences within
> “gene deserts” — so called because they are completely devoid of genes —
> can regulate gene activity elsewhere by forming DNA loops across relatively
> large distances.The study helps solve a mystery about how genetic
> variations in parts of the genome that don’t appear to be doing very much
> can increase cancer risk.Their study, published in Nature Communications,
> also has implications for the study of other complex genetic diseases.The
> researchers developed a technique called Capture Hi-C to investigate
> long-range physical interactions between stretches of DNA – allowing them
> to look at how specific areas of chromosomes interact physically in more
> detail.The researchers assessed 14 regions of DNA that contain
> single-letter variations previously linked to bowel cancer risk. They
> detected significant long-range interactions for all 14 regions, confirming
> their role in gene regulation.“Our new technique shows that genetic
> variations are able to increase cancer risk through long-range looping
> interactions with cancer-causing genes elsewhere in the genome,” study
> leader Professor Richard Houlston, Professor of Molecular and Population
> Genetics at The Institute of Cancer Research, London said.“It is sometimes
> described as analogous to a wormhole, where distortions in space and time
> could in theory bring together distant parts of the universe.”The research
> was funded by the EU, Cancer Research UK, Leukaemia & Lymphoma Research,
> and The Institute of Cancer Research (ICR).
> >
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> ----------------------------------------------------------------------------
>
> Prof Russell Standish Phone 0425 253119 (mobile)
> Principal, High Performance Coders
> Visiting Professor of Mathematics hpc...@hpcoders.com.au
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