need help - cause of unknown nonregenerative anemia

[Hideyo Yamamoto]

Hi, I just got back from ultrasound appointment for my ayumi - her left
side of top wall is very enlarged -and she has non regenerative anemia -
does heart problem cause anemia?  Also her BP is very low even with
epogen (about 55) - she does not have FIP or cancer - or any parasite -
what could it be?   Her PCV is 18 now and scheduling for transfusion in
two weeks if epogen does not work for her - any insight is appreciated.