Dear Jorge, Thank you for your comments on Conrad's contribution to the field of biocomputing and the reference, which, I see, is from 1988.
You wrote:
The model presented suggests that projection processes that are masked in
ordinary laboratory systems are brought to macroscopic significance by the
highly nonlinear chain of amplification events in the biological cell."
Is this not, however, the question this discussion began with, namely, what new
(or old, thanks Koichiro) evidence is there that the interactions between
micro- and macro-world actually occur?
Please correct me if you are talking, here, about different parts of the
fluctuon model and if so can you clarify which?
Thanks and best wishes,
Joseph
----- Original Message -----
From: Jorge Navarro López
To: fis@listas.unizar.es
Sent: Thursday, October 28, 2010 2:34 PM
Subject: [Fis] Tactilizing processing
Dear FIS people,
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As a new comer to Systems Biology and graduated in Chemical Engineering, I
can say little (and understand only a little bit) about the fluctuon model. May
I say that personally I find far more interesting the pioneering ideas of M.
Conrad on molecular bio-computing, which were also inspired by his "vertical"
view of the information flows. For instance, nowadays protein complexes are
recognized as a fundamental aspect of the proteome. About this matter, some FIS
people will enjoy the following abstract:
"Proteins and other macromolecules may be viewed as shape-based (or tactile)
pattern recognizers. Biological cells exploit this inherent capability by
transducing macroscopic signal patterns impinging on the external membrane to
microscopic patterns at the molecular level, via second messengers. The
parallelism inherent in the wave function description of these microscale
processes in effect serves to increase the computing power of molecular
computing systems as compared to macroscopic analogs. The conversion and
recognition process is highly reminiscent of measurement. The linking role of
second messengers allows macroscopic signals to set the state of the cell (in
analogy to state preparation), while enzymatic readout and control of cellular
behavior is an amplification process that corresponds to measurement of the
microstate at a later point of time. Since the standard time evolution
equations are reversible and unitary, while measurement is not, it is
conceivable that the study of molecular computing will lead to new insights
into the relation between the microworld and the macroworld. The model
presented suggests that projection processes that are masked in ordinary
laboratory systems are brought to macroscopic significance by the highly
nonlinear chain of amplification events in the biological cell."
Quantum mechanics and molecular computing: Mutual implications
Michael Conrad
DOI: 10.1002/qua.560340725
International Journal of Quantum Chemistry
Supplement: Proceedings of the International Symposium on Quantum Biology and
Quantum Pharmacology
Volume 34, Issue S15, pages 287-301, 12/19 March 1988
Best wishes!!!!
Jorge
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