Dear Professor Torday,
thank you for your insightful analysis of the complex system which is genetics. Your viewpoints cover from the molecular, cellular, physiological level up to that of cosmic changes affecting the whole of the Earth. Your work is truly a tour d’horizon of the subject. Random mutation or natural selection: this is a relatively minor aspect of the overall interdependence. On this subject it may be helpful to take a look at what the numbers say. The Darwin concept of survival of the fittest creates a linear order among the animals: fittest thru the medium down to the least fit, which get eaten and therefore by their absence in the genetic pool influence the future composition of the multitude. External influences exist and they exert their influence by creating a sorted collection. The pressure exerted by natural selection can well be modelled by simple arithmetic of sorting. Having at least two external influences at work at any time, one may assume that in the multitude the laws of transition between two orders are valid. (For the organism it may be of advantage to have more fat, to be well prepared for the winter; having more fat may be irrelevant for the ability to make mimicry.) Competing external influences may well bring forth situations, where the organism has to decide whether to be prepared for future danger type A or for future danger type B. This is the moment where random mutation can appear. Being sorted and ordered in aspects A and B means that there exist groups among elements that make the change together. The element does not change its position on its own: it is embedded in a community with other elements, forming a kind of convoy, a string, a filament. Permutations consist of cycles. The concept of cycles brings a temporal dimension to the proceedings. The cycle elements *e* are in, progresses through slices of logical truth: each such a moment which is true is true for one element *e_i*, had been true just before for one element *e_(i-1)*, and will be true just next for one element *e_(i+1)*. Cycles of interest being composed of more than a very few members, such elements of the corpus, which will be true later, are a potential subject of seduction. Assuming that there is concurrently a reordering procedure between aspects C and D, there are great chances that any element that is not being certified true, may change its properties before being nailed down by truth having arrived for him, too. Lots of room for random results. Random mutation can well be connected to the mechanisms that govern natural selection. The two ideas are not unreconciliable. There are many more ideas in your expose which can be supported by the numbers. The numbers are here, ready to serve you. 2018-01-03 16:15 GMT+01:00 JOHN TORDAY <jtor...@ucla.edu>: > Dear FIS Colleagues, I have attached my New Year Lecture at the invitation > of Professor Pedro Clemente Marijuan Fernandez. The content relates a novel > perspective on the mechanism of evolution from a cellular-molecular > vantage-point. I welcome any and all comments and criticisms in the spirit > of sharing ideas openly and constructively. Best Wishes, > > John S. Torday PhD > Professor > Evolutionary Medicine > UCLA > > _______________________________________________ > Fis mailing list > Fis@listas.unizar.es > http://listas.unizar.es/cgi-bin/mailman/listinfo/fis > >
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