Error 10061 means 
cite:
--------------------------------------------------------------------------------
Connection refused.
No connection could be made because the target computer actively refused it.
This usually results from trying to connect to a service that is inactive on the
foreign host—that is, one with no server application 
running.--------------------------------------------------------------------------------


Download support libraries from link you see on the bottom FTP connection
settings dialog
Unpack it into PSPad folder
Ensure you checked Use SSL/TLS if available option in FTP connection settings

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