I just forget to add.
We tried to rebuild php and modules with WITHOUT_LINKTHR=false (default is true) w/o any visible changes. I also the this in failures column of vmstat -z, may it be somehow related to the issue?

ITEM        SIZE     LIMIT      USED      FREE  REQUESTS  FAILURES
32 Bucket:  280,        0,      263,        3,      263,        1
64 Bucket:  536,        0,      323,        6,      329,       93
128 Bucket:1048,        0,     1937,        1,     8897,    21199
tcptw:       72,     5150,     4256,      894,  4862309,     6966

--
Regards,
Ruslan
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