Can you include the previous emails in your current email?
On 12/14/2021 3:46 PM, Laura Willers de Souza wrote:
External Email - Use Caution
Dear Douglas,
Thank you so much for your answer!
Sorry, but I don't think I explained myself correctly in the previous
email.
I want to analyze the difference in cortical thickness between two
groups (CU and CI), adjusting for a covariate (cortisol CSF) and the
interaction between them.
So my model would be: cortical thickness ~ diagnosis + CSF cortisol +
diagnosis*CSF cortisol
Using the GLM DODS, the contrasts, according to the wiki example
(https://surfer.nmr.mgh.harvard.edu/fswiki/Fsgdf2G1V
<https://secure-web.cisco.com/1qbucUNWhNS-2uW6Lox1w2bMK8EUHU0lm2XC7ywMcgAz1opgFdJ9TpOloRtF1uTmyVc70aldT5QkaELBu9kC0X6YiGpVUzZ3hV6ImEDrYAPF9VgAmDOudc6SysPVlhaUvzzGFirVYNLChsA_roK3faZNzYnWbdGPEJSgasor3qtQpKeAN7XvnQ4X24hWQfi35Rh8kF9yIsndHzOZGNxOdCH7U2CUMc9KxEL3N9u2-8weS-Fz01NHj2B_xMyBA8BlbS0n_wekioRXCPViGU3a_0zVQxE5Wu9sLPwFsQ3peECtbgAqHVmzWbyks9AhB3fWY/https%3A%2F%2Fsurfer.nmr.mgh.harvard.edu%2Ffswiki%2FFsgdf2G1V>),
would be:
* To verify if only the diagnosis regression coefficient is
significant (diagnosis changes cortical thickness regardless of
cortisol):
*
1 -1 0 0
*
*
To verify if the regression coefficient of the interaction between
diagnosis and cortisol is significant (the two change cortical
thickness dependently):
*
0 0 1 -1
*
*
To verify if only the cortisol regression coefficient is
significant (cortisol changes cortical thickness regardless of
diagnosis):
*
0 0 0.5 0.5
Are these contrasts corret to represent the model we designed?
Thank you so much again!
Best regards,
*Laura Willers de Souza *
Master Student in Biochemistry
Zimmer Lab - Federal University of Rio Grande do Sul
- Porto Alegre/RS - Brazil
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