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Dear Malte
Thank you so much. I've tried both rigid and affine transformations, and
I've attached a snapshot that shows how the CC doesn't fully overlap with
the template. I'm using a high-quality DTI image and am wondering if
incorporating a T1 image would help improve the registration. I'm not sure
how to apply a two-step registration, if that's even possible, using
mri_synthmorph. Thanks for your guidance.

Best,
John

On Fri, Sep 1, 2023 at 1:27 PM Hoffmann, Malte,PhD <
mhoffm...@mgh.harvard.edu> wrote:

>         External Email - Use Caution
>
> Hi John,
>
> Currently, the default transformation model is "deform". Could you check
> if "affine" yields a better result?
>
> mri_synthmorph -m affine fa.nii.gz template.nii.gz -o fa_in_MNI.nii.gz
>
> Cheers,
> Malte
>
> ________________________________________
> From: freesurfer-boun...@nmr.mgh.harvard.edu <
> freesurfer-boun...@nmr.mgh.harvard.edu> on behalf of John Anderson <
> jb19790...@gmail.com>
> Sent: Friday, September 1, 2023 12:45
> To: Freesurfer support list
> Subject: [Freesurfer] mri_synthmorph
>
>         External Email - Use Caution
>
> Dear Freesurfer experts,
> I processed DTI data using dt_recon, and I want to register FA images to
> the standard MNI152 space. However, after running the command
> mri_synthmorph fa.nii.gz template.nii.gz -o fa_in_MNI.nii.gz,
>
> the registration is not accurate. I'm not sure what I've done wrong. Thank
> you for any guidance.
>
> sincerely
> J
>
>
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