https://gcc.gnu.org/bugzilla/show_bug.cgi?id=66358
--- Comment #14 from Oleg Endo <olegendo at gcc dot gnu.org> --- It seems the problem is adjacent insns that need R0: (insn 10503 2627 2628 402 (set (reg:SI 2424) (sign_extend:SI (mem:QI (plus:SI (reg/v/f:SI 243 [ p2 ]) (const_int 2 [0x2])) [0 MEM[(unsigned char *)p2_97 + 2B]+0 S1 A8]))) ../../ORIG/trunk/libiberty/regex.c:7109 232 {*extendqisi2_compact_mem_disp} (nil)) (note 2628 10503 10505 402 NOTE_INSN_DELETED) (insn 10505 2628 2629 402 (set (reg:SI 2425) (sign_extend:SI (mem:QI (plus:SI (reg/f:SI 774 [ D.8751 ]) (const_int 5 [0x5])) [0 MEM[(unsigned char *)_1000 + 5B]+0 S1 A8]))) ../../ORIG/trunk/libiberty/regex.c:7109 232 {*extendqisi2_compact_mem_disp} (nil)) (note 2629 10505 2631 402 NOTE_INSN_DELETED) (note 2631 2629 10507 402 NOTE_INSN_DELETED) (insn 10507 2631 2633 402 (set (reg:SI 147 t) (eq:SI (and:SI (reg:SI 2424) (reg:SI 2425)) (const_int 0 [0]))) ../../ORIG/trunk/libiberty/regex.c:7109 1 {tstsi_t} (expr_list:REG_DEAD (reg:SI 2425) (expr_list:REG_DEAD (reg:SI 2424) (nil)))) In insn 10503 reg 2424 will be allocated to R0 and will remain live until insn 10507. Reload then fails to insert a move insn R0 -> other reg after insn 10503 and R0 allocation for insn 10505 becomes impossible. I've observed this issue already a while ago. I think this condition can be improved using some sort of linear register allocator for R0-insns.