Hello Nitish,

The change is due to an update at NCBI on 27-DEC-2009.

http://www.ncbi.nlm.nih.gov/nuccore/160358777?report=genbank

We hope this helps,
Jennifer


> Hello,
> 
> I have a question about the mouse HMGCR gene sequence (RefSeq:
> NM_008255). The 
> genomic size of this gene has earlier been reported to be 21514 bp in
> the UCSC 
> genome browser.
> 
> However, the UCSC genome browser now shows the genomic size to be
> 21973 bp. 
> Comparison of the earlier UCSC version with the present version shows
> that now 
> you have added 88 nucleotides in the upstream of exon 1 and 371
> nucleotides in 
> the downstream of 3'UTR. Please see the attached file that shows about
> the added 
> nucleotides.
> 
> Could you please let me know about the reason (e.g. any recent
> experimental 
> report?) for addition of these extra nucleotides in the Exon 1 and
> 3'-UTR of 
> this gene?
> 
> Thanking you and expecting an early response,
> 
> Nitish Mahapatra
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