Hello,

I downloaded UCSC gene annotation track as follows:

http://genome.ucsc.edu/cgi-bin/hgTables
group: 'Genes and Gene Prediction Tracks'
track: 'UCSC Genes'
table: 'knownGene'

The table looks like:
#name   chrom   strand  txStart txEnd   cdsStart        cdsEnd  
exonCount       exonStarts      exonEnds        proteinID       alignID
uc001aaa.2      chr1    +       1115    4121    1115    1115    3       
1115,2475,3083, 2090,2584,4121,         uc001aaa.2
uc009vip.1      chr1    +       1115    4272    1115    1115    2       
1115,2475,      2090,4272,              uc009vip.1
uc009vis.1      chr1    -       4268    6628    4268    4268    4       
4268,4832,5658,6469,    4692,4901,5805,6628,            uc009vis.1
uc001aag.1      chr1    -       5658    7231    5658    5658    4       
5658,6469,6738,7095,    5810,6628,6918,7231,            uc001aag.1

I have few questions:

1. Why do cdsStart and cdsEnd have the same coordinate? I would think 
that cdsStart should coincide with first exon's start and cdsEnd should 
coincide with the last exon's end.
2. In some cases cdsStart differs from cdsEnd but also differs from 
first exon's start, and cdsEnd differs from the last exon's end. For 
example:

uc001abe.2      chr1    -       653074  654579  653880  654321  1       
653074, 654579,         uc001abe.2

Could you please explain what are cdsStart and cdsEnd?

Thank you,
Maria



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