Dear Genome Help,

I was using liftOver to convert a large number of positions in Hg18 to Hg19
coordinates (Human).  It runs great except one position was lifted to a
different chromosome.  I tried it on both the cmdline tool and the online
one, the results are the same.

The trouble position (as input) is

chr7:69506-69506

was lifted to

chr16:90228418-90228418

I choose Human Hg18 to Human Hg19 and left the other selections as default
values.  The cmd I used was

./liftOver -positions oldfile hg18ToHg19.over.chain newfile unmapped

I expect the result should be either on the same chromosome or unmapped.
How do you explain this?

Thanks,

Pei

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Pei Lin
Software Engineer III
Broad Institute
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