Good Morning Archie:

Please note the difference in data value resolution between the values you 
obtain
from the .wib files with hgWiggle, and the original ascii data values you find 
in
the wigFix files.  Note the "Known issues section:" at 
http://genomewiki.ucsc.edu/index.php/Wiggle

hgWiggle is the convenient query mechanism to work with the wiggle data sets 
with
the caveat of the loss in resolution of the data values.  And yes, it can work 
on
whole chromosome, or even whole genome queries.  The original ascii data files
have the non-lossy data values, but they are simple ascii data files with no
indexing available to allow convenient access.  If you have a spread sheet or R 
system
which can handle a couple billion numbers in one table, you could perhaps throw 
all
those numbers into that system.  I'm not familiar with what procedures you 
would use there
to manipulate such a set of numbers.  See also:
http://genomewiki.ucsc.edu/index.php/Using_hgWiggle_without_a_database

You could convert the wigFix files into bigWig files to avoid the loss of 
resolution.
However, the query utilities into bigWig files are going to return ascii data 
values, or
summaries in regions.  You would again need to manage the returned ascii data 
values.
See also:  
http://genomewiki.ucsc.edu/index.php/Selecting_a_graphing_track_data_format

--Hiram

Archie Russell wrote:
> Thanks
> 
> Will hgWiggle work for whole chromosomes?
> 
> Could I also use the "wigFix" files (they are in ascii)
> 
> Thanks,
>  Archie
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