See also: http://genomewiki.ucsc.edu/index.php/Big_file_converters
Are you sure your wiggle file is legitimate ? 16Gb compressed sounds like it is much too verbose. Even if it had a data value for each base in the human genome, it should be less than 5 Gb compressed. For example, here is a set of files that cover the complete human genome and their total size is 4.6Gb: http://hgdownload.cse.ucsc.edu/goldenPath/hg19/phyloP46way/vertebrate/ --Hiram ----- Original Message ----- From: "Peng Yu" <[email protected]> To: [email protected] Sent: Thursday, March 29, 2012 8:36:17 PM Subject: [Genome] Generating large bigWig file Hi, I have a large wig file (about 16GB gzipped), it seems that wigToBigWig takes too much memory. Of course, it is possible to generated multiple bw files for each genome chunk (suppose that I break the input file to multiple pieces). But it is inconvenient to view many bw files and I don't fine a tool that can combine bw files directly. I'm wondering if there is a way to generate a single bigWig file for such a large input. Would any export let me know? Thanks! -- Regards, Peng _______________________________________________ Genome maillist - [email protected] https://lists.soe.ucsc.edu/mailman/listinfo/genome
