On Thu, Sep 25, 2014 at 9:00 AM, Matthew George Liptrot <
matthew.lipt...@di.ku.dk> wrote:

>  Hi,
>
>  I am a novice at handling surfaces, and at using the Connectome
> Workbench/commandline, so apologies if the following is obvious.
>
>  We want to be able to perform connectivity analysis of subjects (both
> HCP and our own) using diffusion tractography. In order to directly compare
> the resultant (voxel-to-voxel) connectivity matrices across subjects, we
> would like to have a one-to-one correspondence between the tractography
> seed voxels in each subject. I presume that the best way to do this would
> be to first select the desired set of (inter-subject matched) seed points
> upon the aligned surface meshes already provided (BIG thanks!) by the HCP
> and then convert them to the (nearest) voxel? (I realise that this may be a
> surjective mapping). Are there functions/commands within the Connectome
> Workbench that can do this? Or are there more sensible approaches to
> achieving this?
>

We don't seed cortex tractography from voxels, we seed from surfaces.  FSL
tractography supports this:

http://fsl.fmrib.ox.ac.uk/fsl/fslwiki/FDT/UserGuide#Using_surfaces

Then we use workbench commands to convert the outputs as needed for viewing
in workbench, and to stitch the two cortex pieces and any volume pieces
together into one file, etc.

Also, in [1], it states that the ‘standard grayordinate space’ (in CIFTI
> format) is used for achieving bijective inter-subject correspondence of the
> WM surface vertices and the subcortical voxels. However, I’m a bit confused
> how this bijective correspondence is maintained during the resampling from
> the 164K to the 32K meshes i.e. does the adaptive barycentric surface
> resampling method guarantee that the 32K-to-32K mappings are also bijective?
>

The resampling of an individual surface from one atlas mesh to another uses
the atlas spheres, not the subject spheres, so you get the same mesh and
vertex correspondence every time.  Also, we do surface resampling with
barycentric, not adaptive barycentric area resampling, because "signal
loss" doesn't really apply to coordinate data - barycentric resampling
doesn't add smoothness when downsampling, so it stays closer to the
original anatomical contours in areas with curvature.

Tim

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