Hello,
I would like to segment spheroids that are in microcavities.
For the first cell, all is ok.
Here are a few lines from my macro:
run("Duplicate...", " ");
run("Invert LUT");
setAutoThreshold("Moments dark");
setOption("BlackBackground", true);
run("Convert to Mask");
run("Invert LUT");
run("Analyze Particles...", "size=6000-80000 display summarize add");

For the second cell, my problem is that I'm working in white light and the 
edges of the wells are also detected ....
One solution might be to do a threshold on the edges of the wells and the 
outside and remove these areas, then do a new threshold to detect spheroids, 
but I don't know how to write these lines of code ... :-(

Thanks for any help and/or suggestions you can give me.
Good day to all
Patricia

The images are here :
https://filesender.renater.fr/?s=download&token=f580e06e-6f9a-4e4b-8696-b99037472bdc


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