I don't understand the part of your question about it working without a screen reader. As far as that goes its like any other piece of software if the person needs a screen reader then they'll need one with Dragon.
If they are trying to run Dragon and Jaws then they need JSay, the Jaws interface programme. Since Dragon responds to verbal commands it hears its really pretty impossible to work it without an interface because it hears and tries to respond to Jaws. Hope your friend finds a system that works for them! Joy For answers to frequently asked questions about this list visit: http://www.jaws-users.com/help/