The details of this thread are well above my expertise, but I read 
something that looks relevant and interesting in a HN thread 
<https://news.ycombinator.com/item?id=16318677> on PyQt:

I have been developing in HTML/Python for a while now. This works 
> wonderfully. You just need to put all your business logic in Python, use 
> PyQt to run all the platform specific code like file dialogs, printing, 
> etc. but keep the main interface with React. You do that by having a 
> webview with a service object being the bridge between Python and the JS 
> view[0]. If you are a bit careful with the amount of information going 
> through the bridge, you get very good performance (source 
> <https://news.ycombinator.com/item?id=16319154>)


Apologies if this is not relevant.

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