I can confirm that 2.16.0, at least, works with 10.7.4. As far as building the binaries, however, my experience has been negative. I have been unable to compile LilyPond on my machine, either manually or using homebrew. I have reported the issue on the devel list (http://lists.gnu.org/archive/html/lilypond-devel/2012-09/msg00452.html), and hopefully one of the wizards will take a few moments to examine it as it is reproducible and not limited to my machine.
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