We just got a new CIO at the university where I work. One thing he is about to do is get rid of all the different mail systems and have one big combined system for all employees and students. That'll be about 50,000 users.We run a single M$ E2K server for around 1000 users and it needs fairly intense admin... especially as the information stores are around the 200GB mark.
Lotus Domino server will run on Linux so throw that in as an option for a more stable server over the W2K base.
However Outlook is a better PIM than the Lotus Notes Variety.
Will clients want to synchronize PDA's? etc....
There are solutions provided by the big linux providers http://www.suse.de/en/business/products/suse_business/openexchange/
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